She was one of the guests of honour at her friend Tom Cruise’s lavish Italian wedding to Katie Holmes in 2006.
But Scientology’s celebrity favourites have distanced themselves from Leah Remini, 43, since she sensationally left the church last week.
On Tuesday, reports surfaced that Kirstie Alley – another outspoken defender of the controversial religion – was livid with Remini over the defection, although she’s since denied the claims, however, it seems that Remini has one supporter from her A-list days, in the shape of Jennifer Lopez.
According to People, Lopez, 43, a non-Scientology, has got the Brooklyn girl’s back.
‘They’re best friends and they’re fine,’ Leah’s sister Nicole Remini-Wiskow told the magazine.
‘None of her Scientology friends are sticking by her side. I guess you really learn who your friends are.’
Last week, former Village Voice editor Tony Ortega alleged in his Scientology blog that Alley was ‘livid’ at Remini for leaving in such a high profile fashion.
He also quoted a cryptic Tweet from last week: ‘When faced w malicious gossip I take a moment to experience the loss of the person I thought was my friend… Then I say [bleep] em..:) #RISE’
What’s the story? Kirstie Alley – pictured on Monday night in Hollywood – has denied she’s livid with Remini for her public defection
Close: Tom Cruise with old friend Remini at the War of the Worlds premiere in Los Angeles in 2005
Where it all started: Leah began to question the church after Tom and Katie’s 2006 wedding, it has been claimed
However, on Monday the 62-year-old Alley Tweeted: ‘Lying news outlets. I do NOT care what religion ANYONE is or isn’t. I respect religions & would fight for your freedom as well as mine.’
She continued: ‘Thank U lying “news” outlets for thinking I have ESP & write tweets “BEFORE” events OCCUR. I accept that compliment. Ur “sources” don’t exist.’
Remini’s relationship actually started to unravel the night of Cruise’s wedding, and Lopez was there to witness it.
According to sources, the King of Queens star spent the night chatting with Jennifer in the hotel bar; cloistered at the heart of Tom’s celebrity circle.
But then she had the temerity to ask Scientology leader David Miscavige the whereabouts of his wife Shelly.
And the interaction with Kirstie Alley took another turn for the intriguing on Wednesday.
After Leah’s sister Nicole alleged that Alley ignored Leah’s pleas to help Staten Island after Superstorm Sandy, Alley Tweeted: ‘Need ur opinion. “IF there was a whopping lie about U floating around, would U make statement or let it pass? I’d appreciate your views. : )’
Earlier, in a series of no-holds-barred, cryptic tweets posted on July 10, Kristie appeared to slam her friend of 30 years for spreading what she called ‘malicious gossip’.
‘When faced w malicious gossip I take a moment to experience the loss of the person I thought was my friend… Then I say f*** em..:)’ she posted to her more than one million followers.
Six hours later, she followed up with ‘the sweetest poison is often served with a smile…beware syrup’ as she allegedly arrived at long-time Church member Melinda Brownstone’s home for crisis talks.
Melinda was said to have been Leah’s oldest and best friend, having met when she first moved to LA at the tender age of 13, however, all members have reportedly been instructed to ‘disconnect’ from the star immediately.
Former King Of Queens star Leah joined the Church with her mother in the 1970s after relocating to Los Angeles from Brooklyn to pursue her acting dream.
The way they were: Pictured together on an episode of King Of Queens, Kirstie and Leah have known each other for years
Long history: Kirstie has been a very vocal supporter of the Church Of Scientology since discovering the organisation in 1979.
Leah reportedly called time on her association following years of interrogation for questioning the whereabouts of leader David Miscavige’s wife, Shelly, who hasn’t been seen since 2007.
In a statement released to People magazine on July 11, the 43-year-old thanked the public for supporting her decision to cut ties with the controversial church.
‘I wish to share my sincere and heartfelt appreciation for the overwhelming positive response I have received from the media, my colleagues, and from fans around the world. I am truly grateful and thankful for all your support.’
Meanwhile, deep in conversation on her phone as she made her way to the Mustard Seed Cafe in Los Feliz on July 13, Kirstie wasn’t able to muster a smile as she seemingly had the weight of the world on her shoulders.
The mother-of-two appeared not to have ran a comb through her hair or put on a lick of make-up.
A good distraction: The 62-year-old is currently busy working on a new sitcom, aptly titled Kirstie’s New Show, which will premiere in the fall.
Kirstie has been a very vocal supporter of the Church of Scientology since she became affiliated with them through a Narconon program that based its techniques on their beliefs and practices in 1979.
She credits the Church with helping her overcome her cocaine addiction.
‘To tell you the honest-to-God truth: without Scientology, I would be dead. So, I can personally highly recommend it,’ she says
Other famous long-time celebrity Scientology devotees include Tom Cruise, John Travolta, Jenna Elfman and Juliette Lewis.
MailOnline has reached out to Kirstie’s spokesperson for comment but is yet to receive a response.
Household name: Remini in a still for King of Queens with Kevin James and Jerry Stiller
Emergency meeting: A-list members of the Church Of Scientology’s Celebrity Centre International in Hollywood allegedly gathered on July 10 to discuss how to deal with Leah’s defection